Fig. 2
From: 15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
The pro-apoptotic effects of 15-LOX 1 in breast cancer cells. 15-LOX may mediate the regulation of breast cancer cell death by inducing apoptosis. Activation of 15-LOX and exogenous 13-HODE administration induce apoptosis and cell cycle arrest in doxorubicin-resistant MCF-7 cells [32]. Also, 15-LOX-1 mediates pro-apoptotic effects of Trichostatin A in MCF-7 and MDA-MB-231 cells possibly through elevation of 13-HODE [9]. sodium butyrate induced apoptosis in breast cancer cells through activation of 15-LOX-1 activity and transcript level [43]