Fig. 3
From: 15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
The effect of Linoleic acid-rich diet on 15-LOX activity and breast tumor behavior (In-vivo evidence). Changes in the activity of enzymes involved in fat metabolism can affect the fate of tumor cells. LA-enriched diet supplemented with indomethacin-induced 15-LOX metabolites and reduced breast tumor size in nude mice [45]. The peanut oil-enriched diet enriched by ω-3 and ω9 PUFAs caused elevation of membrane arachidonic acid (AA) content and reduced activity of 15-LOX-2 and 15-LOX-1 that was accompanied by increased apoptosis and decrease mitosis in murine mammary gland adenocarcinoma [52]. The conjugated linoleic acid (CLA) in pregnant and breastfeeding female rats was associated with reduced LOX metabolites and enzyme activity lower risk of mammary tumor size induced by chemicals in their offspring [51, 53]