Fig. 4
From: 15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
The effect of exogenous lipid metabolism modulation on breast cancer cell behavior and 15-LOX metabolites (In-vitro evidence). Various compounds that target the metabolism of fatty acids could be effective in the growth and invasion of breast tumor cells through lipoxygenase metabolites. Docosahexaenoic acid reduced tumor cell growth, cell proliferation, tumor-induced angiogenesis through inhibition of 15-HETE synthesis [47]. The cAMP content, activity of Erk1/2 and 13-HODE synthesis were suppressed following linoleic acid isomers administration [48]. The conjugated linoleic acid (CLA) reduced the level of 15-HETE and 5-HETE while exogenous arachidonic acid stimulated production of 15(S)-HETE and phosphorylation of p38 MAPK [54]. The linoleic acid-rich supplement stimulates the production of PGE2, 12-HETE, and 15-HETE which was associated with tumor cell invasion [46]