Fig. 5
From: 15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
The effect of 15-LOX and its mediators on breast cancer cell metastasis and invasion. The 15-LOX activity can affect breast cancer cell metastasis and invasion through various pathways. Inhibition of 15-LOX activity leads to reduced MCF7 spheroid formation and metastasis to the lymph node [61]. The MCF-7 cell exposure to EPA and GLA induced the production of 15(S)-HETE and 13(S)-HODE [63]. 15-LOX-1accounts as a positive activator of CREB that mediates breast cancer cell metastasis [64]. 15-LOX-1 suppression using novel purine-pyrazole hybrids induced MCF-7 cell death, however; 15-LOX inhibition using NDGA caused TMT-081 cell growth suppression, reduced DNA synthesis, and 13-HODE formation [40, 64, 67]. The attachment of breast cancer cells to the lymph-endothelial cells facilitates using 12(S)-HETE generation by 15-LOX-1 [61, 62]