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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing AdipoR2

Fig. 1

Overview of sphingolipid metabolism. Species in red were measured in the present study both in terms of their total abundance and in terms of their fatty acid composition; a palmitate is shown in blue, but other fatty acids may be present. Two enzymes of particular interest are indicated in green: serine palmitoyltransferase is the rate limiting step in de novo ceramide synthesis while a ceramidase activity has been attributed to the AdipoRs

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