Fig. 1From: Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing AdipoR2Overview of sphingolipid metabolism. Species in red were measured in the present study both in terms of their total abundance and in terms of their fatty acid composition; a palmitate is shown in blue, but other fatty acids may be present. Two enzymes of particular interest are indicated in green: serine palmitoyltransferase is the rate limiting step in de novo ceramide synthesis while a ceramidase activity has been attributed to the AdipoRsBack to article page