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Table 1 Baseline characteristics in study patients with and without events

From: NAFLD fibrosis score is correlated with PCSK9 and improves outcome prediction of PCSK9 in patients with chest pain: a cohort study

Variables

Total

Events

Non-events

P

n = 2008

n = 158

n = 1850

Clinical data

 Age (years)

55.5 ± 10.9

57.5 ± 9.6

55.3 ± 11.0

0.017

 Male sex, n(%)

1215 (60.6)

101 (63.9)

1114 (60.2)

0.360

 BMI (kg/m2)

25.7 ± 3.4

26.0 ± 3.5

25.6 ± 3.4

0.185

 CAD, n(%)

1179 (58.7)

121 (76.6)

1058 (57.2)

< 0.0001

 DM, n(%)

471 (23.5)

54 (34.2)

417 (22.5)

0.001

 Hypertension, n(%)

1229 (61.2)

107 (67.7)

1122 (60.6)

0.080

 Family history of CAD, n(%)

440 (21.9)

22 (13.9)

418 (22.6)

0.011

 Smoking, n(%)

683 (34.0)

56 (35.4)

627 (33.9)

0.693

 Drinking, n(%)

417 (20.8)

35 (22.2)

382 (20.6)

0.655

 SBP (mmHg)

127.6 ± 18.5

130 ± 16.9

127.4 ± 18.7

0.099

 DBP (mmHg)

79.5 ± 11.2

79.8 ± 11.8

79.5 ± 11.1

0.710

Laboratory parameters

 Platelet (109/L)

216.0 ± 53.6

208.7 ± 51.1

216.6 ± 53.8

0.075

 ALT (IU/L)

20 (14,28)

21 (14,29)

20 (14,28)

0.472

 AST (IU/L)

18 (15,22)

18 (14.75,22)

18 (15,22)

0.806

 GGT (IU/L)

25 (18,39)

30 (21,44.25)

25 (18,39)

< 0.0001

 ALB (g/L)

42.5 ± 4.3

41.9 ± 3.8

42.6 ± 4.3

0.060

 TC (mmol/L)

4.80 ± 1.01

5.00 ± 0.94

4.80 ± 1.01

0.095

 TG (mmol/L)

1.60 (1.15,2.31)

1.60 (1.24,2.36)

1.60 (1.14,2.30)

0.541

 HDL-C (mmol/L)

1.11 ± 0.39

1.13 ± 0.35

1.11 ± 0.39

0.539

 LDL-C (mmol/L)

3.13 ± 0.91

3.24 ± 0.81

3.12 ± 0.92

0.128

 Glucose (mmol/L)

5.66 ± 1.96

5.91 ± 2.61

5.64 ± 1.90

0.094

 HbA1C (%)

6.05 ± 1.88

6.3 ± 1.11

6.03 ± 1.93

0.081

 PCSK9 (ng/mL)

228.56 (190.57,272.29)

245.23 (204.53,292.15)

227.58 (189.93,270.97)

0.002

 NFS

−1.09(−1.98,-0.27)

−0.77(−1.53,0.05)

−1.12(−2.00,-0.29)

< 0.0001

Medication

 Antiplatelet drugs, n(%)

595 (29.6)

65 (41.4)

530 (28.6)

0.001

 Antihypertensive drugs, n(%)

694 (34.6)

67 (42.4)

627 (33.9)

0.031

  1. PCSK9 proprotein convertase subtilisin/kexin type 9, BMI body mass index, CAD coronary artery disease, DM diabetes mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma-glutamyl transpeptidase, ALB albumin, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HbA1C hemoglobin A1C, NFS non-alcoholic fatty liver disease fibrosis score, P <  0.05 suggests significant difference