Fig. 5
From: Fat mass and obesity–associated protein promotes liver steatosis by targeting PPARα
FTO promotes hepatic steatosis in mice. A, B C57BL/6J male mice were administered the AAV8-FTO (AAV8-FTO) or control (AAV8-Con) vector by tail vein injection, then fed a high-fat diet (HFD) for 8 weeks. Body weights were recorded at the indicated time points (n = 6 mice per group). C-F Representative images of Oil Red O staining (200x magnification) in the liver tissues of FTO-overexpressing and control mice fed an HFD for 8 weeks (n = 6 mice in each group). G Quantification of Oil Red O staining area in hepatocytes by the ImageJ software