Fig. 7
From: Fat mass and obesity–associated protein promotes liver steatosis by targeting PPARα
FTO induces lipid accumulation in hepatocytes by targeting PPARα. A-D FTO-overexpressing (Lenti-FTO) and control HepG2 cells (Lenti-NC) were treated with palmitic acid (PA) (0.5 mM) for 24 h without (A, C) or with (B, D) challenge with the PPARα agonist, GW7647 (10 µM). Oil Red O staining was performed and photographed at 200x magnification (n = 3 independent experiments)