Fig. 8

Interactions of GR with HNF4α and PPARα in gene regulation. A Analysis of ChIP-sequencing data of DNA-binding of epigenetic signatures, HNF4α, and GR in gene loci in wildtype mouse liver. B Analysis of ChIP-sequencing data of DNA-binding of GR and PPARα in gene loci in wildtype mouse liver. C - F Dual-luciferase assays of promoter/intron activities of mouse genes (C-D), human POR and SETDB2 (E), as well as human CD36, human PLIN2, human SREBP-1C, and mouse Srebp-1c (F) genes in HEK293 cells 24 h after transfection with firefly reporter vectors, pRL-CMV, and expression vectors for HNF4α, GR (with 10 nM dexamethasone), or PPARα (with 10 μM clofibrate). N=4 per group, mean ± SE. * P < 0.05 versus control; # P < 0.05 versus HNF4α or PPARα alone