Fig. 9

Effects of liver-specific knockout (KO) of glucocorticoid receptor (GR) on hepatic mRNA expression and lipid metabolism in high-fat-high-sugar (HFHS)-fed adult male mice. A & B Liver histology (H & E staining, 5 μm, 400X); C blood glucose; D liver/body weight ratio; E hepatic lipids, and F & G real-time PCR quantification of hepatic mRNAs. N = 6-7 per group, mean ± SE. Hepatic mRNAs were normalized to Pgk1, with wildtype values set at 1.0 or 100%. * P < 0.05 versus wildtype (WT) control