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Table 4 Multivariable adjusted odds ratio (OR)s and 95% confidence interval (CI)s of BMI of 25 kg/m2 or greater according to the distribution of lipid profiles among premenopausal breast cancer survivors

From: Association of lipid profile with obesity among breast cancer survivors: a cross-sectional study

  ORsa and 95% CIs of BMI of 25 kg/m2 or greater by plasma lipid markers
Lipid Profile Tertile 1 Tertile 2 Tertile 3 P-trend
Cholesterol (mmol/L)
 Total-C 1.00 1.91 (0.87, 4.20) 0.90 (0.40, 2.02) 0.61
 non-HDL-C 1.00 1.82 (0.83, 3.99) 1.35 (0.62, 2.96) 0.54
 Remnant-C 1.00 2.10 (0.94, 4.71) 1.68 (0.76, 3.71) 0.26
 VLDL-C 1.00 3.04 (1.34, 6.94) 2.43 (1.05, 5.60) 0.08
 Clinical LDL-C 1.00 1.32 (0.62, 2.81) 0.86 (0.38, 1.91) 0.80
 LDL-Cb 1.00 1.54 (0.72, 3.32) 0.95 (0.43, 2.13) 0.91
 HDL-C 1.00 0.99 (0.47, 2.07) 0.43 (0.19, 0.96) 0.04
Triglycerides (mmol/L)
 Total-TG 1.00 1.99 (0.88, 4.50) 2.74 (1.23, 6.10) 0.003
 VLDL-TG 1.00 3.03 (1.34, 6.84) 2.81 (1.23, 6.46) 0.03
 LDL-TG 1.00 1.30 (0.58, 2.90) 2.16 (0.99, 4.70) 0.11
 HDL-TG 1.00 1.04 (0.47, 2.31) 1.74 (0.80, 3.80) 0.09
Phospholipids (mmol/L)
 Total-PL 1.00 1.26 (0.58, 2.76) 0.97 (0.45, 2.09) 0.96
 VLDL-PL 1.00 2.27 (1.00, 5.15) 2.86 (1.27, 6.43) 0.01
 LDL-PL 1.00 1.41 (0.66, 3.03) 0.90 (0.40, 1.99) 0.78
 HDL-PL 1.00 1.25 (0.58, 2.70) 0.63 (0.29 1.38) 0.54
Cholesteryl esters (mmol/L)
 Total-CE 1.00 2.27 (1.02, 5.03) 0.98 (0.43, 2.21) 0.80
 VLDL-CE 1.00 2.49 (1.10, 5.62) 2.25 (0.99, 5.11) 0.09
 LDL-CE 1.00 1.05 (0.49, 2.25) 0.58 (0.27, 1.26) 0.69
 HDL-CE 1.00 1.16 (0.55, 2.43) 0.46 (0.20, 1.03) 0.04
Free Cholesterol (mmol/L)
 Total-FC 1.00 2.72 (1.24, 5.99) 1.18 (0.51, 2.68) 0.64
 VLDL-FC 1.00 2.08 (0.93, 4.63) 2.50 (1.13, 5.56) 0.03
 LDL-FC 1.00 1.20 (0.56, 2.56) 0.70 (0.31, 1.57) 0.41
 HDL-FC 1.00 0.99 (0.46, 2.11) 0.59 (0.27, 1.29) 0.18
Total Lipids (mmol/L)
 Total-L 1.00 1.23 (0.56, 2.72) 1.33 (0.61, 2.91) 0.50
 VLDL-L 1.00 1.77 (0.77, 4.07) 3.24 (1.45, 7.21) 0.002
 LDL-L 1.00 2.40 (1.10, 5.26) 1.15 (0.51, 2.62) 0.72
 HDL-L 1.00 1.59 (0.73, 3.45) 0.72 (0.31, 1.61) 0.28
Lipoprotein particle (mmol/L)
 Total-LP 1.00 1.01 (0.47, 2.17) 0.69 (0.32, 1.50) 0.67
 VLDL-LP 1.00 2.03 (0.88, 4.65) 2.99 (1.33, 6.69) 0.02
 LDL-LP 1.00 1.51 (0.69, 3.33) 1.50 (0.70, 3.24) 0.33
 HDL-LP 1.00 1.04 (0.48, 2.25) 0.77 (0.36, 1.66) 0.44
Lipoprotein particle sizes (nm)
 VLDL-p 1.00 2.12 (0.93, 4.85) 3.16 (1.41, 7.03) 0.004
 LDL-p 1.00 0.83 (0.40, 1.71) 0.53 (0.24, 1.18) 0.08
 HDL-p 1.00 0.60 (0.28, 1.26) 0.28 (0.13, 0.64)  < 0.001§
  1. aModels were adjusted for age (years, continuous), highest education completed (middle school, high school, college education and above), ever smoked (no, yes), current alcohol use (no, yes), family history of breast cancer (no, yes), history of chronic disease (no, yes) and physical activity (MET-hours/week, continuous)
  2. bLDL-C was estimated from Friedewald’s equation. Clinical LDL-C and LDL-C are the same biomarker but refer to different definition methods [30]
  3. §P-trend was signifincant at Bonferroni corrected P-value = 0.00147