Table 1 Baseline characteristics of subjects. Assessment after the run-in phase (week 2)

Age (years)

56.5 (52.3, 58.8)

52.0 (46.8, 58)

51.0 (47, 56.5)

0.373

Sex (% male)

50

50

50

BMI (kg/m²)

25.20 (21.0, 26.8)

24.60 (22.5, 28.2)

25.35 (23.8, 27.4)

0.778

Glucose (mmol/L)

4.68 (4.5, 5.0)

5.10 (4.7, 5.4)

4.73 (4.4, 5.0)

0.260

Insulin (mU/L)

5.00 (3.3, 6.3)

5.75 (3.5, 7.9)

3.65 (1.9, 4.4)

0.040*

Total cholesterol (mmol/L)

5.035 (4.6, 5.3)

4.895 (4.0, 5.6)

4.465 (4.3, 5.0)

0.338

HDL-C (mmol/L)

1.49 (1.3, 1.8)

1.36 (1.1, 1.5)

1.33 (1.2, 1.7)

0.401

LDL-C (mmol/L)

3.22 (2.8, 3.7)

3.06 (2.6, 3.8)

2.67 (2.5, 3.3)

0.193

Ox-LDL Ab (mU/ml)

254 (162, 476)

483 (347, 1394)

811 (411, 1167)

0.092

Triglycerides (mmol/L)

0.87 (0.75, 1.0)

0.89 (0.62, 1.4)

0.66 (0.58, 0.92)

0.314

Lp-a (mg/L)

0.13 (0.11, 0.35)

0.20 (0.08, 0.47)

0.12 (0.04, 0.8)

0.933

Apo A1 (g/L)

2.61 (1.3, 3.4)

2.05 (1.5, 2.4)

2.14 (1.7, 2.8)

0.457

Apo B (g/L)

0.87 (0.29, 1.23)

0.78 (0.41, 1.02)

1.05 (0.86, 1.39)

0.156

hs-CRP (mg/L)

0.6 (0.24, 1.49)

0.96 (0.7, 1.98)

0.82 (0.5, 2.09)

0.371

IL-6 (pg/ml)

0.74 (0.65, 0.98)

0.7 (0.6, 0.96)

1.09 (0.97, 1.38)

0.027*

TNFα (pg/ml)

2.40 (2, 5)

3.37 (1, 5.2)

3.81 (1.8, 7.2)

0.701

TNF-Receptor 1 (pg/ml)

798 (705, 974)

995 (941, 1103)

1197 (997, 1395)

0.007**

TNF-Receptor 2 (pg/ml)

2636 (2290, 4089)

2664 (2457, 3406)

1748 (1461, 2098)

0.033*

ELAM-1 (ng/ml)

2.5 (1.6, 3.4)

2.6 (1.2, 4.8)

5.5 (3.9, 8.2)

0.007**

Endothelin (pg/ml)

1.9 (1.6, 2.7)

2 (1.7, 2.3)

1.7 (1.3)

0.638

ICAM (ng/ml)

17.5 (10, 32.4)

19.1 (10.9, 32.2)

25.8 (20.7, 29.7)

0.274

VCAM (ng/ml)

212 (124, 320)

150 (113, 241)

286 (183, 415)

0.099