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Table 3 Outcome variables (serum) at baseline and the end of treatment

From: N-3 fatty acid supplementation mediates lipid profile, including small dense LDL, when combined with statins: a randomized double blind placebo controlled trial

Parameter (mmol/L)

Placebo (n = 21)

n-3 FA (n = 20)

P

Mean ± SD

Mean ± SD

TG

Baseline

1.61 ± 0.85

1.62 ± 0.60

0.924

8 week

1.66 ± 0.86

1.29 ± 0.37

0.090

% Difference

6.20 ± 10.14*

−21.51 ± 12.15***

< 0.001***

TC

Baseline

4.97 ± 0.81

4.91 ± 0.72

0.820

8 week

5.05 ± 0.83

4.55 ± 0.65

0.049*

% Difference

2.06 ± 2.97**

−6.55 ± 3.59***

< 0.001***

HDL-C

Baseline

1.40 ± 0.47

1.34 ± 0.32

0.677

8 week

1.42 ± 0.49

1.37 ± 0.30

0.716

% Difference

2.90 ± 6.73*

1.09 ± 6.97

0.403

Non-HDL-C

Baseline

3.55 ± 0.60

3.47 ± 0.59

0.999

8 week

3.62 ± 0.72

3.20 ± 0.54

0.042*

% Difference

4.65 ± 21.00

−9.47 ± 4.58***

0.007**

LDL-C

Baseline

2.61 ± 0.65

2.66 ± 0.61

0.831

8 week

2.64 ± 0.61

2.64 ± 0.55

0.985

% Difference

0.91 ± 4.35

−0.08 ± 5.20

0.510

VLDL-C

Baseline

0.93 ± 0.25

0.90 ± 0.29

0.684

8 week

0.98 ± 0.25

0.55 ± 0.20

< 0.001***

% Difference

3.95 ± 9.93

−36.88 ± 11.75***

< 0.001***

LDL-C I

Baseline

1.07 ± 0.35

1.03 ± 0.30

0.689

8 week

1.08 ± 0.36

1.03 ± 0.24

0.647

% Difference

1.41 ± 10.21

3.89 ± 15.73

0.551

LDL II

Baseline

0.56 ± 0.20

0.63 ± 0.26

0.381

8 week

0.56 ± 0.19

0.67 ± 0.30

0.209

% Difference

−0.74 ± 16.24

1.55 ± 17.27

0.664

LDL III

median (Q1, Q3)

Baseline

0.05 (0.02, 0.10)

0.09 (0.05, 0.15)

0.158

8 week

0.05 (0.02, 0.10)

0.02 (0.00, 0.08)

0.090

% Difference

0 (0, 0)

−67.5 (−100, −31.25)**

< 0.001***

  1. Q1: First quartile, Q3: Third quartile *P < 0.05, ** P < 0.01, *** P < 0.001
  2. P-value represents difference between groups at the relevant timepoint for each parameter. P-value for % difference represents the effect of intervention for that parameter