Fig. 4
![Fig. 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12944-022-01693-z/MediaObjects/12944_2022_1693_Fig4_HTML.png)
Hypoxia induces MIF regulating lipid metabolism through activating IL-6/JAK/STAT signaling. Hep2 cells were treated with 25 μM ISO-1 under hypoxia. Then the mRNA (A) and protein level (B) of IL-6 were assessed by qRT-PCR and western blot. C The intersection gene expressions of JAK/STAT gene sets and differently expressed genes in RNA seq were verified. D TG concentration of Hep2 cells treated with XL019 or solvent under hypoxia. The data are presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001