Fig. 4

Changes in community diversity and bacterial species abundance in the chronic-binge ApoH^−/− mouse model. A, B Bacterial composition at phylum (A) and genus (B) levels in WT and ApoH^−/− mice fed alcohol and their pair-fed controls. C-E Alpha diversities of WT and ApoH^−/− mice and their alcohol-fed counterparts were analyzed and displayed using the Shannon index of OTU level temporally (P > 0.05). F, G Alpha diversity of enterobacteria from ApoH^−/− mice after 15-day chronic alcohol feeding (F) and alcohol binging (G). H, I Beta diversity of WT and ApoH^−/− mice fed an alcohol diet and their pair-fed controls, where (H) shows the PCA plot, and (I) shows the boxplot representing the distribution of samples in different groups along the PC1 axis