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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Alcohol-dependent downregulation of apolipoprotein H exacerbates fatty liver and gut microbiota dysbiosis in mice

Fig. 6

Model representing the function of ApoH in alcohol-induced liver injury. In the chronic and binge ethanol mouse models, alcohol downregulated ApoH expression to aggravate fatty liver and gut microbiota dysbiosis. Specifically, alcohol downregulated ApoH expression to activate the oxidation–reduction process, particularly the CYP450 enzymes system, and induced dysbiosis of lipid metabolism in ALD. The downregulation of ApoH caused an imbalance in the intestinal micro-ecological environment and resulted in functional metabolic disorders of the gut microbiota in mice

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Lipids in Health and Disease

ISSN: 1476-511X