Utility of traditional and non-traditional lipid indicators in the diagnosis of nonalcoholic fatty liver disease in a Japanese population

Lu, Song; Kuang, Maobin; Yue, Jinjing; Hu, Chong; Sheng, Guotai; Zou, Yang

doi:10.1186/s12944-022-01712-z

Lipids in Health and Disease

Table 5 The best threshold, sensitivities, specificities, and area under the curve of lipid-related parameters for the screening of NAFLD in different age groups

From: Utility of traditional and non-traditional lipid indicators in the diagnosis of nonalcoholic fatty liver disease in a Japanese population

	AUC	95%CI low	95%CI upp	Best threshold	Specificity	Sensitivity
< 30 years old
TC	0.73	0.60	0.86	4.90	0.76	0.68
HDL-C	0.85	0.76	0.94	1.09	0.92	0.68
LDL-C	0.82	0.72	0.92	2.85	0.75	0.86
TG	0.91	0.87	0.96	0.75	0.84	0.86
Non-HDL-C	0.85	0.77	0.93	3.63	0.85	0.77
RC	0.92	0.87	0.97	0.53	0.84	0.91
TC/HDL-C ratio	0.92	0.87	0.97	3.86	0.89	0.82
TG/HDL-C ratio	0.93	0.89	0.97	0.44	0.73	1.00
LDL-C/HDL-C ratio	0.91	0.86	0.96	2.09	0.76	0.91
Non-HDL-C/HDL-C ratio	0.92	0.87	0.97	2.86	0.89	0.82
RC/HDL-C ratio	0.93	0.89	0.98	0.40	0.85	0.86
30–44 years old
TC	0.67	0.65	0.69	5.21	0.70	0.57
HDL-C	0.78	0.77	0.80	1.34	0.66	0.79
LDL-C	0.73	0.72	0.75	3.12	0.68	0.67
TG	0.83	0.81	0.84	0.85	0.74	0.76
Non-HDL-C	0.77	0.76	0.78	3.77	0.73	0.69
RC	0.83	0.82	0.84	0.55	0.70	0.82
TC/HDL-C ratio	0.83	0.82	0.84	3.70	0.70	0.83
TG/HDL-C	0.84	0.83	0.85	0.63	0.74	0.80
LDL-C/HDL-C ratio	0.82	0.81	0.83	2.27	0.69	0.82
Non-HDL-C/HDL-C ratio	0.83	0.82	0.84	2.70	0.70	0.83
RC/HDL-C ratio	0.85	0.84	0.86	0.40	0.70	0.85
45–59 years old
TC	0.56	0.54	0.58	5.21	0.46	0.64
HDL-C	0.74	0.72	0.75	1.30	0.68	0.69
LDL-C	0.63	0.61	0.65	3.46	0.63	0.57
TG	0.76	0.74	0.77	0.94	0.67	0.71
Non-HDL-C	0.67	0.65	0.68	4.04	0.62	0.64
RC	0.75	0.73	0.76	0.63	0.69	0.70
TC/HDL-C ratio	0.75	0.74	0.77	4.11	0.70	0.71
TG/HDL-C ratio	0.78	0.76	0.79	0.73	0.70	0.73
LDL-C/HDL-C ratio	0.74	0.73	0.76	2.47	0.63	0.75
Non-HDL-C/HDL-C ratio	0.75	0.74	0.77	3.11	0.70	0.71
RC/HDL-C ratio	0.78	0.76	0.79	0.43	0.62	0.80
≥ 60 years old
TC	0.56	0.50	0.62	5.29	0.43	0.72
HDL-C	0.64	0.58	0.69	1.34	0.56	0.69
LDL-C	0.61	0.55	0.66	3.13	0.40	0.79
TG	0.67	0.61	0.73	0.98	0.62	0.64
Non-HDL-C	0.64	0.58	0.69	4.42	0.72	0.50
RC	0.67	0.62	0.73	0.63	0.61	0.65
TC/HDL-C ratio	0.67	0.62	0.72	3.84	0.52	0.76
TG/HDL-C ratio	0.68	0.62	0.73	0.91	0.75	0.53
LDL-C/HDL-C ratio	0.66	0.61	0.72	2.46	0.54	0.75
Non-HDL-C/HDL-C ratio	0.67	0.62	0.72	2.84	0.52	0.76
RC/HDL-C ratio	0.68	0.63	0.74	0.48	0.64	0.64

Abbreviations: AUC: area under the curve; other abbreviations as in Table 1

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