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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC

Fig. 3

WY-14,643 suppresses ccRCC cell migration. a. Photographs of wound gaps were taken 12 h after scratching (left) and cell migration percentages were calculated (right) in 786-O cells. b. In A498 cells, photographs of wound gaps were taken 12 h after scratching (left) and cell migration percentages were calculated (right). c. After pretreatment with WY-14,643, a Transwell assay was conducted to assess cell migration and images were taken. Magnification, 100x. d and e. Cell migration percentages were calculated. f and g. After treatment with various doses of WY-14,643, mesenchymal markers were detected by western blotting and analyzed quantitatively (n = 3). *P < 0.05, **P < 0.01. WY, WY-14,643

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Lipids in Health and Disease

ISSN: 1476-511X