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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC

Fig. 5

WY-14,643 facilitates triglyceride consumption in ccRCC cells. a. After 48 h-treatment with 200 µM WY-14,643, lipid droplets in ccRCC cells were evaluated by Oil red O staining. Magnification, 400x. b and c. The OD values at 490 nm were quantitatively measured. d and e. Neutral lipid levels were evaluated by Nile red staining after treatment with WY-14,643 at the indicated doses for 48 h, and images were captured. Magnification, 200x. f and g. The intracellular glycerol content was measured after 48 h-treatment with WY-14,643 at the indicated doses in 786-O and A498 cells. *P < 0.05, **P < 0.01. WY, WY-14,643

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Lipids in Health and Disease

ISSN: 1476-511X