Skip to main content
Fig. 6 | Lipids in Health and Disease

Fig. 6

From: WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC

Fig. 6

WY-14,643 upregulates CPT1A in ccRCC cells. a. PPI evaluated by STRING. b and c. In ccRCC, gene correlation analysis between PPARα and CPT1A through UALCAN and GEPIA. d. Specific doses of WY-14,643 were administered, and relative CPT1A mRNA expression levels were analyzed in 786-O cells (n = 3). e. Specified doses of WY-14,643 were treated, and CPT1A protein expression levels were detected and analyzed quantitatively in 786-O cells (n = 3). f. Different concentrations of WY-14,643 were applied, and relative CPT1A mRNA expression levels were analyzed in A498 cells (n = 3). g. Different concentrations of WY-14,643 were administered, and CPT1A protein expression levels were detected and analyzed quantitatively in A498 cells (n = 3). *P < 0.05, **P < 0.01. WY, WY-14,643

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X