Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study

Table 2 Hazard ratios for MACCEs according to the median TyG index level and variability

	Number	Number of events (%)	Model 1		Model 2		Model 3
			HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Baseline TyG index
< 8.59	553	24 (4.3)	Reference	–	Reference	–	Reference	–
8.59–9.08	572	32 (5.6)	1.29 (0.76, 2.18)	0.351	1.34 (0.79, 2.28)	0.279	1.31 (0.77, 2.22)	0.325
≥ 9.08	569	44 (7.7)	1.86 (1.13, 3.06)	0.014	1.97 (1.19, 3.25)	0.008	1.76 (1.06, 2.93)	0.030
Mean TyG index
< 8.53	552	18 (3.3)	Reference	–	Reference	–	Reference	–
8.53–8.93	574	29 (5.1)	1.62 (0.9, 2.92)	0.108	1.64 (0.91, 2.96)	0.098	1.59 (0.88, 2.86)	0.125
≥ 8.93	568	53 (9.3)	3.04 (1.78, 5.18)	< 0.001	3.21 (1.87, 5.51)	< 0.001	2.72 (1.57, 4.74)	< 0.001
TyG index-SD
< 0.15	545	20 (3.7)	Reference	–	Reference	–	Reference	–
0.15–0.26	563	31 (5.5)	1.49 (0.85, 2.62)	0.162	1.51 (0.86, 2.64)	0.153	1.51 (0.86, 2.65)	0.151
≥ 0.26	586	49 (8.4)	2.31 (1.37, 3.88)	0.002	2.39 (1.42, 4.02)	0.001	2.17 (1.28, 3.68)	0.004

CI confidence interval; MACCE, major advent cardiovascular and cerebrovascular event; HR, hazard ratio; SD, standard deviation; TyG, triglyceride glucose
Model 1, unadjusted model; Model 2, adjusted for age and sex; Model 3, adjusted for variables in model 2 plus hypertension, dyslipidemia, diabetes mellitus, prior MI, prior PCI, prior CABG, mean stent diameter, β-blocker, oral hypoglycemic agents, insulin, baseline LDL-C, baseline TC, baseline HDL-C, baseline HbA1C for baseline TyG index; or adjusted for variables in model 2 plus hypertension, dyslipidemia, diabetes mellitus, prior MI, prior PCI, prior CABG, mean stent diameter, β-blocker, oral hypoglycemic agents, insulin, baseline LDL-C, baseline TC, baseline TG, baseline HDL-C, baseline FPG, baseline HbA1C and baseline TyG index for mean TyG index and TyG index-SD

ISSN: 1476-511X