Sex-related differences in single nucleotide polymorphisms associated with dyslipidemia in a Korean population

Table 1 Characteristics of all the study subjects

Variables	Categories	HEXA(Discovery)			CAVAS(Replication)			KARE(Replication)
		Dyslipidemia (n = 15,054)	Nondyslipidemia (n = 37,395)		Dyslipidemia (n = 2743)	Nondyslipidemia (n = 2912)		Dyslipidemia (n = 2309)	Nondyslipidemia (n = 3184)
		n(%) or M ± SD	n(%) or M ± SD	p	n(%) or M ± SD	n(%) or M ± SD	p	n(%) or M ± SD	n(%) or M ± SD	p
Sex	Male	5848(38.9)	12,402(33.2)	< 0.001***	1104(40.2)	1043(35.8)	< 0.001***	1303(56.4)	1313(41.2)	< 0.001***
Sex	Female	9206(61.1)	24,993(66.8)	< 0.001***	1639(59.8)	1869(64.2)	< 0.001***	1006(43.6)	1871(58.8)	< 0.001***
Age (years)		58.58 ± 7.77	58.53 ± 8.30	0.087	60.89 ± 8.37	60.40 ± 9.02	< 0.05*	52.21 ± 8.33	51.07 ± 8.60	< 0.001***
BMI (kg/m²)		24.54 ± 2.87	23.62 ± 2.92	< 0.001***	24.91 ± 3.04	23.91 ± 3.16	< 0.001***	25.37 ± 2.80	24.05 ± 2.98	< 0.001***
TC (mg/dL)		224.51 ± 45.30	189.19 ± 27.96	< 0.001***	202.25 ± 41.41	189.77 ± 25.84	< 0.001***	213.78 ± 41.49	188.31 ± 26.39	< 0.001***
HDL-C (mg/dL)		51.21 ± 16.82	60.72 ± 73.73	< 0.001***	39.40 ± 9.99	51.70 ± 10.10	< 0.001***	43.37 ± 10.50	53.59 ± 10.24	< 0.001***
TG (mg/dL)		184.01 ± 112.03	100.94 ± 37.24	< 0.001***	183.18 ± 96.22	107.19 ± 37.10	< 0.001***	216.86 ± 140.55	106.45 ± 38.68	< 0.001***
LDL-C (mg/dL)		138.84 ± 41.25	108.28 ± 26.08	< 0.001***	127.73 ± 37.74	116.63 ± 24.23	< 0.001***	130.89 ± 38.72	113.44 ± 24.91	< 0.001***

M mean, SD standard deviation, P p value, BMI body mass index, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, ***p < 0.001, ** p < 0.01, * p < 0.05

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