Serum lipid profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-center retrospective study

Table 4 Lipid parameters of the subjects in the intervention study at baseline and at last

Serum lipid profile	L-treatment group, (n= 77)			Dietary treatment group, (n = 87)			Con group, (n = 407)
Serum lipid profile	Before	After	Δ^a	Before	After	Δ	Before	After	Δ^b
TC^c,average,mmol/L	6.41	6.45	*0.05*	6.16	6.42	*0.26*	6.02	6.33	*0.31*
TG,median, mmol/L	2.41	3.01	*0.72*	2.44	3.26	*0.68*	2.01	2.55	*0.49*
HDL-C,average,mmol/L	1.91	1.75	*-0.17*	1.80	1.65	*-0.15*	1.89	1.77	*-0.13*
LDL-C,average,mmol/L	3.24	3.34	*0.09*	3.13	3.19	*0.06*	3.02	3.35	*0.32*
Apo A1,average,mmol/L	2.23	2.20	*-0.07*	2.10	2.05	*-0.04*	2.14	2.13	*-0.01*
Apo B,average,mmol/L	1.07	1.17	*0.11*	1.06	1.12	*0.06*	1.00	1.13	*0.12*

^aΔ: Postintervention lipid indexes minus preintervention indexes. ^bThe lipid indicators in the control group were used as the fundamental levels of raised blood lipids during pregnancy. ^cBefore intervention, the rise range of TC was much higher in the dietary-treatment group (0.26 mmol/L) than in the L-treatment group (0.05 mmol/L) after the intervention (P = 0.035)

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