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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis

Fig. 4

Interaction of miR-375-3p with ATG2B. A The binding of miR-375-3p to AGO2 was verified by AGO2-RIP experiment. B Data from bioinformatics (TargetScan) confirmed the combination. C Effect of transfection of the miR-375-3p inhibitor in HepG2 and Huh-7 cells. D The protein expression after transfection of ATG2B-LV was detected by Western Blot. E Green fluorescent protein to point out transfection effectivity in HepG2 cells triggered by using FFA. F Western Blot detection of LC3, P62, NLRP3, cleaved-caspase-1, and IL-1β protein expression. G LC3 and NLRP3 expression as detected via fluorescence microscopy. *P < 0.05, **P < 0.01, ***P < 0.001

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Lipids in Health and Disease

ISSN: 1476-511X