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Table 4 Change of lipoprotein particle diameters and volumes after fastinga

From: NMR derived changes of lipoprotein particle concentrations related to impaired fasting glucose, impaired glucose tolerance, or manifest type 2 diabetes mellitus

 

Fasting state

Control

IFG

IGT

IFG + IGT

T2D

Nf

 

196

167

21

29

19

Nnf

 

251

193

26

68

57

Lipoprotein

 HDL total

Fasting

     

  (7 – 16 nm)

 < d > [nm]

8.62

8.55

8.61

8.59

8.52

 < V > [nm3]

721

701

717

711

693

Non-Fasting

     

 < d > [nm]

8.60

8.57

8.60

8.58

8.53

 < V > [nm3]

715

707

716

709

694

Δdnf-f [%]

-0.26

0.23

-0.05

-0.06

0.06

ΔVnf-f [%]

-0.87

0.75

-0.10

-0.25

0.18

Δcnf-f [%]

0.9

3.9

-0.1

0.9

3.6

 LDL total

Fasting

     

  (16 – 30 nm)

 < d > [nm]

20.0

20.2

20.1

20.2

20.2

 < V > [nm3]

9.07E + 3

9.27E + 3

9.14E + 3

9.29E + 3

9.28E + 3

Non-Fasting

     

 < d > [nm]

20.0

20.1

20.1

20.1

20.2

 < V > [nm3]

9.10E + 3

9.20E + 3

9.19E + 3

9.25E + 3

9.35E + 3

Δdnf-f [%]

0.16

-0.27

0.20

-0.13

0.20

ΔVnf-f [%]

0.31

-0.72

0.57

-0.39

0.74

Δcnf-f [%]

0.1

3.6

-0.6

-1.30

6.7

 IDL and VLDL

Fasting

     

  (30 – 80 nm)

 < d > [nm]

42.3

42.4

42.4

42.7

42.4

 < V > [nm3]

9.06E + 4

9.15E + 4

9.15E + 4

9.38E + 4

9.12E + 4

Non-Fasting

     

 < d > [nm]

42.2

42.4

42.5

42.6

42.7

 < V > [nm3]

9.05E + 4

9.16E + 4

9.22E + 4

9.30E + 4

9.32E + 4

Δdnf-f [%]

-0.06

0.04

0.25

-0.23

0.62

ΔVnf-f [%]

-0.14

0.11

0.76

-0.87

2.18

Δcnf-f [%]

1.5

1.7

4.8

-4.5

11.8

 CM total

Fasting

     

  (80 – 430 nm)

 < d > [nm]

121

121

120

123

119

 < V > [nm3]

4.55E + 6

4.54E + 6

4.44E + 6

4.88E + 6

4.24E + 6

Non-Fasting

     

 < d > [nm]

121

121

120

122

121

 < V > [nm3]

4.47E + 6

4.54E + 6

4.35E + 6

4.69E + 6

4.52E + 6

Δdnf-f [%]

-0.36

-0.09

-0.42

-0.94

1.72

ΔVnf-f [%]

-1.84

0.08

-2.01

-3.99

6.75

Δcnf-f [%]

0.0

3.3

9.1

-7.8

20.2

  1. aThe fasting values are from the spectra taken before the oGTT, the non-fasting vales were extrapolated to time t = 0 from the spectra of reserve samples of the blood donors. < d > , average particle diameter and < V > average volume calculated with the diameters given in Methods assuming a spherical shape.. Δdnf-f, ΔVnf-f, and Δcnf-f, relative differences (in %) of particle diameters, volumes, and concentrations under non-fasting conditions minus those under fasting conditions. Nf and Nnf , number of participants analysed under fasting or non-fasting conditions, respectively. Differences of mean values between fasting and non-fasting subjects with an error probability ≤ 0.05 are presented in bold letters