Fig. 1
From: HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation
LPS + LDL but not LPS + HDL ameliorates LPS-induced sickness behaviour. Adult male C57BL/6 mice received an intraperitoneal injection of either saline (n = 9), LPS (0.5 mg/kg, n = 11) or LPS mixed with lipoprotein immediately prior to administration (HDL, n = 6, 20 mg/kg; LDL, n = 5, 20 mg/kg). 6 h post-injection, animals completed an open field behavioural test, and grid crossings (A) and number of rears (B) were recorded. Data are presented as Tukey boxplots with Sidak’s test for multiple comparisons, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001