Fig. 3
From: HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation
LPS perturbed plasma metabolites which were not recovered with lipoprotein co-administration. Adult male C57BL/6 mice received an intraperitoneal injection of either saline (n = 9), LPS (0.5 mg/kg, n = 11) or LPS mixed with lipoprotein immediately prior to administration (HDL, n = 6, 20 mg/kg; LDL, n = 5, 20 mg/kg). Metabolites driving differences between treatment groups by principal component analysis were evaluated. Relative amounts of valine (A), isoleucine (B), glutamate (C), glutamine (D), lysine (E) and phenylalanine (F) were determined. Data are presented as Tukey boxplots analysed by one-way ANOVA with Sidak’s test for multiple comparisons, *p < 0.05, **p < 0.01, ****p < 0.0001