Fig. 5
From: HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation
LPS perturbs liver metabolites which are partially recovered by LDL co-administration. Adult male C57BL/6 mice received an intraperitoneal injection of either saline (n = 9), LPS (0.5 mg/kg, n = 11) or LPS mixed with lipoprotein immediately prior to administration (HDL, n = 6, 20 mg/kg; LDL, n = 5, 20 mg/kg). Metabolites driving differences between treatment groups by principal component analysis were evaluated. Relative amounts of glutamate (A), glutamine (B), N-acetylcysteine (C), succinate (D), acetate (E), glucose (F) and taurine (G) were determined. Data are presented as Tukey boxplots analysed by one-way ANOVA with Sidak’s test for multiple comparisons, *p < 0.05 **p < 0.01 ***p < 0.001 ****p < 0.0001