Table 1 Summary of the key metabolomic changes in the plasma, liver, and brain by LPS and/or lipoprotein treatment group

PLASMA

VALINE

1.41****

1.29**

1.32***

1.17

0.96

ISOLEUCINE

1.35****

1.34****

1.27***

1.17*

1.01

GLUTAMATE

1.32****

1.23**

1.21*

0.91

0.91

GLUTAMINE

1.21*

1.14*

1.15*

0.92

0.94

LYSINE

1.27****

1.14

1.16

0.96

0.91

PHENYLALANINE

1.49****

1.37***

1.45****

1.09

1.04

MYO-INOSITOL

1.34****

1.23***

1.22**

0.90

0.98

ΒCH₂ LIPOPROTEIN

1.25****

1.18**

1.08

0.88

0.90

CITRATE

1.39****

1.33**

1.17

0.85

0.94

GLUCOSE

0.61****

0.60****

0.78

0.85

0.79

HDL

1.17

1.45****

1.25

1.40****

0.96

LDL

1.09

1.35

1.11

1.35

1.13

LIVER

GLUTAMATE

1.80****

1.77****

1.78****

1.02

0.89

GLUTAMINE

1.40***

1.69****

1.29

0.94

0.76

 N-ACETYLCYSTEINE

1.33*

1.37*

1.19

1.16

0.79

SUCCINATE

1.29*

1.41***

1.25

1.06

0.93

ACETATE

1.23*

1.19

1.23

0.99

0.94

GLUCOSE

0.56***

0.44***

0.57**

0.90

1.21

TAURINE

0.67**

0.51****

0.74

0.79

1.12

BRAIN

LACTATE

0.88***

0.82****

0.84***

0.87**

0.88

ADENOSINE MONOPHOSPHATE

1.40***

1.34*

1.25

1.15

1.01

ASPARTATE

0.84

0.77*

0.72*

0.74*

0.93

VALINE

1.13

1.17*

1.20*

1.12

1.11

NAD

0.87

0.52*

0.78

0.74

0.60

CITRATE

1.02

1.01

1.07*

1.00

1.09**

LPS (ENDOTOXIN)

1.04

1.20****

1.12**

1.01

0.99

HDL

1.16

1.25

1.29

1.28

1.29

LDL

1.10

1.14

1.18

1.19

1.22