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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo

Fig. 4

Photomicrographs of the effects of estradiol and selected antihyperlipidemic drugs on the ascending aorta of ovariectomized Wistar rats fed with thermoxidized soya oil diet. (4a) Sham (4b) OVX (4c) OVX + TSO (4d) ATV (4e) EZE + ATV (4f) ETD

Note the thickening of the tunica media (TM) indicated by the small yellow arrow and aortic recanalization indicated by the big yellow arrow in OVX + TSO (c). Note the reduced amount of red blood cells in the luminal aspect of the aortic wall and the preservation of the elastic laminae of the tunica media indicated by TM in ATV, EZE + ATV and ETD treatment groups. H&E staining of the rat aorta (x100 magnification)

OVX – ovariectomy; TSO – thermoxidised soya oil; EC – endothelial cells; TM – tunica media; TI – tunica intima; TA – tunica adventitial; PAT – peri-adventitial fat; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol

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Lipids in Health and Disease

ISSN: 1476-511X