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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo

Fig. 6

Photomicrographs of the effects of estradiol and selected antihyperlipidemic drugs on the thoracic aorta of ovariectomized Wistar rats fed with thermoxidized soya oil diet. (6a) Sham (6b) OVX (6c) OVX + TSO (6d) ATV (6e) EZE + ATV (6f) ETD

Note the accumulation of large amount of red blood cells indicated by the yellow arrow; thickness of tunica media and complete disruption of the elastic laminae indicated by the white arrow and increased deposition of peri-adventitial fat (PAT) indicated by the red arrow in (c). Note the preservation of the elastic laminae of the tunica media, indicated by TM in (d-f). H&E staining of the rat aorta (x100 magnification)

OVX – ovariectomy; TSO – thermoxidized soya oil; EC – endothelial cells; TM – tunica media; TI – tunica intima; TA – tunica adventitia; PAT – peri-adventitial fat; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol

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Lipids in Health and Disease

ISSN: 1476-511X