Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo

Table 1 Effects of estradiol and selected antihyperlipidemic drugs on plasma lipid profile of ovariectomized Wistar rats fed with thermoxidized soya oil diet

Treatment	Plasma Lipid profile parameters (mg/dL)
Treatment	TC	TG	HDL-c	LDL-c	VLDL-c
Sham (Group I)	77.72 ± 1.29	96.23 ± 10.22	22.08 ± 0.77	36.40 ± 2.24	19.25 ± 2.04
OVX	93.58 ± 4.76	104.12 ± 2.01	21.18 ± 0.79	49.62 ± 0.86	21.3 ± 1.34
OVX + TSO	107.89 ± 1.68^#	139.72 ± 21.97^#	19.88 ± 1.21	60.07 ± 7.01^#	27.94 ± 4.39^#
OVX + TSO + ATV	82.35 ± 2.07***	103.20 ± 10.59***	24.53 ± 4.08**	37.17 ± 7.69***	20.64 ± 2.12*
OVX + TSO + EZE + ATV	88.68 ± 2.13***	97.22 ± 18.33***	20.67 ± 1.61	57.21 ± 10.10	19.44 ± 3.67**
OVX + TSO + ETD	76.05 ± 0.94***	104.26 ± 14.06***	20.88 ± 1.64	34.31 ± 10.02***	20.85 ± 2.81*

Values are expressed as mean ± SEM (n = 6)
#p < 0.05 compared to Group I values accepted as significant
*p < 0.05 compared to OVX + TPO
**p < 0.01 compared to OVX + TPO
***p < 0.001 compared to OVX + TPO
OVX – ovariectomized; TSO – thermoxidized soya oil; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol; TC – total cholesterol; TG – triglycerides; HDL-c – high density lipoprotein cholesterol; LDL-c – low density lipoprotein cholesterol; VLDL-c – very low density lipoprotein cholesterol

ISSN: 1476-511X