Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo

Table 2 Effects of estradiol and selected antihyperlipidemic drugs on plasma lipid profile of ovariectomized Wistar rats fed with thermoxidized palm oil diet

Treatment	Plasma Lipid profile parameters (mg/dL)
Treatment	T-CHOL	TRIG	HDL	LDL	VLDL
Sham (Group I)	77.72 ± 1.29	96.23 ± 10.22	22.08 ± 0.77	36.40 ± 2.24	19.25 ± 2.04
OVX	93.58 ± 4.76	104.12 ± 2.01	21.18 ± 0.79	49.62 ± 0.86	21.3 ± 1.34
OVX + TPO	106.95 ± 2.70^#	163.95 ± 16.53^#	20.92 ± 0.60	55.66 ± 4.73^#	30.37 ± 3.63^#
OVX + TPO + ATV	82.49 ± 2.25***	110.45 ± 18.34***	21.48 ± 1.54	38.92 ± 4.62***	22.09 ± 3.67**
OVX + TPO + EZE + ATV	98.54 ± 0.66	114.89 ± 6.68***	20.73 ± 0.69	54.83 ± 1.95	22.98 ± 1.34*
OVX + TPO + ETD	95.33 ± 1.69**	126.19 ± 12.78*	19.54 ± 1.25	50.55 ± 5.32	25.24 ± 2.56

Values are expressed as mean ± standard error of mean (n = 6)
#p < 0.05 compared to Sham accepted as significant
*p < 0.05 compared to OVX + TPO
**p < 0.01 compared to OVX + TPO
***p < 0.001 compared to OVX + TPO
OVX – ovariectomized; TPO – thermoxidized palm oil; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol; TC – total cholesterol; TG – Triglycerides; HDL-c – high density lipoprotein cholesterol; LDL-c – low density lipoprotein cholesterol; VLDL-c – very low density lipoprotein cholesterol.

ISSN: 1476-511X