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Table 3 Effects of estradiol and selected antihyperlipidemic drugs on plasma atherogenic indices of ovariectomized Wistar rats fed with thermoxidized soya oil diet

From: Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo

Treatment

Plasma Atherogenic indices

AI

CRI

HDL-c/LDL-c

Sham (Group I)

3.44 ± 0.59

3.55 ± 0.22

0.62 ± 0.05

OVX

4.71 ± 0.55

4.65 ± 0.33#

0.3 ± 0.04

OVX + TSO

6.03 ± 1.02#

5.57 ± 0.49#

0.36 ± 0.06

OVX + TSO + ATV

3.43 ± 0.41***

3.74 ± 0.52***

1.25 ± 0.32***

OVX + TSO + EZE + ATV

3.86 ± 0.94***

4.90 ± 0.67

0.45 ± 0.11

OVX + TSO + ETD

4.04 ± 0.64**

3.64 ± 0.38***

0.18 ± 0.31

  1. Values are expressed as mean ± SEM (n = 6)
  2. #p < 0.05 compared to Group I values accepted as significant
  3. *p < 0.05 compared to OVX + TSO
  4. **p < 0.01 compared to OVX + TSO
  5. ***p < 0.001 compared to OVX + TSO
  6. OVX – ovariectomized; TSO – thermoxidized soya oil; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol; HDL-c – high density lipoprotein cholesterol; LDL-c – low density lipoprotein cholesterol; AI – atherogenic index; CRI – coronary risk index