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Table 4 Effects of estradiol and selected antihyperlipidemic drugs on plasma atherogenic indices of ovariectomized Wistar rats fed with thermoxidized palm oil diet

From: Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo

Treatment

Plasma Atherogenic indices

AI

CRI

HDL-c/LDL-c

Sham (Group I)

3.44 ± 0.59

3.55 ± 0.22

0.62 ± 0.05

OVX

4.71 ± 0.55

4.65 ± 0.33#

0.3 ± 0.04

OVX + TPO

6.29 ± 0.92#

5.09 ± 0.21#

0.38 ± 0.02

OVX + TPO + ATV

4.21 ± 0.81***

3.88 ± 0.20**

0.57 ± 0.06

OVX + TPO + EZE + ATV

4.58 ± 0.39*

4.78 ± 0.17

0.38 ± 0.02

OVX + TPO + ETD

4.39 ± 0.29**

5.03 ± 0.52

0.42 ± 0.06

  1. Values are expressed as mean ± standard error of mean (n = 6)
  2. # - p < 0.05 compared to Sham accepted as significant
  3. * - p < 0.05 compared to OVX + TPO
  4. ** - p < 0.01 compared to OVX + TPO
  5. *** - p < 0.001 compared to OVX + TPO
  6. OVX – ovariectomized; TPO – thermoxidized palm oil; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol; HDL-c – high density lipoprotein cholesterol; LDL-c – low density lipoprotein cholesterol; AI – atherogenic index; CRI – coronary risk index.
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Lipids in Health and Disease

ISSN: 1476-511X