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Table 1 Univariate and multivariate Cox regression analysis of LT-free 90-day mortality in patients with HEV-triggered ACLF.

From: A new dyslipidemia-based scoring model to predict transplant-free survival in patients with hepatitis E-triggered acute-on-chronic liver failure

Parameters

Nonsurvivors (n = 83)

Survivors (n = 171)

P value

Training set (n = 254)

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Age, (y)

55 ± 14

53 ± 13

0.474

53 ± 14

1.006 (0.990–1.021)

0.466

  

Gender (male)

70 (84.3)

136 (79.5)

0.397

206 (81.1)

1.255 (0.694–2.268)

0.453

  

Alcohol use

31(37.4)

71 (41.5)

0.586

102 (40.2)

    

Cirrhosis

58 (69.9)

85 (49.7)

0.003

143 (56.3)

1.908 (1.187–3.067)

0.008

1.708 (0.980–2.976)

0.059

Ascites

49 (59.0)

43 (25.1)

< 0.001

92 (36.2)

2.668 (1.719–4.141)

< 0.001

1.855 (1.012–3.399)

0.046

Bacterial infection

28 (33.7)

32 (18.7)

0.011

60 (23.6)

1.646 (1.044–2.595)

0.032

0.981 (0.560–1.718)

0.947

Hepatic encephalopathy

35 (42.2)

5 (2.9)

< 0.001

40 (15.7)

3.901 (2.523–6.031)

< 0.001

2.027 (1.218–3.373)

0.007

Gastrointestinal haemorrhage

7 (8.4)

6 (3.5)

0.128

13 (5.1)

1.707 (0.787–3.703)

0.176

  

ALT, U/L

423 (74-1100)

554 (130–1238)

0.863

526 (119–1211)

NA

0.813

  

AST, U/L

155(119–202)

354 (104–955)

0.553

339 (108–990)

NA

0.780

  

Tbil, µmol/L

364 (173–495)

223 (130–327)

< 0.001

246 (140–401)

1.002 (1.001–1.002)

< 0.001

1.000 (0.999–1.001)

0.968

Albumin, g/L

32 ± 5

34.5 ± 5

0.002

33 ± 5

0.952 (0.915–0.990)

0.015

1.031 (0.969–1.096)

0.335

INR

2.10 (1.60–2.85)

1.41 (1.15–1.68)

< 0.001

1.57 (1.13–2.10)

1.531 (1.328–1.765)

< 0.001

1.216 (0.978–1.513)

0.079

Creatinine, µmol/L

68.2 (53.3–83.1)

63.1 (53.9–73.3)

0.068

64.3 (53.8–75.1)

1.002 (1.000-1.003)

0.027

1.000 (0.999–1.002)

0.699

Glucose, mmol/L

4.89 (3.96–6.36)

5.08 (4.10–6.41)

0.273

5.07 (4.09–6.39)

0.965 (0.893–1.044)

0.381

  

WBC, 109/L

6.90 (5.46–10.44)

5.74 (4.16–7.78)

0.001

6.08 (4.43–8.34)

1.080 (1.027–1.135)

0.003

1.027 (0.965–1.093)

0.404

Haemoglobin, g/L

127 (110–142)

127 (114–146)

0.344

127 (113–144)

0.995 (0.986–1.005)

0.337

  

Platelet, 109/L

86 (66–119)

111 (71–153)

0.011

100 (68–146)

0.996 (0.992-1.000)

0.070

  

Cholesterol, mmol/L

2.01 (1.39–2.54)

2.96 (2.38–3.72)

< 0.001

2.63 (2.01–3.24)

0.569 (0.447–0.724)

< 0.001

1.310 (0.891–1.928)

0.170

Triacylglycerol, mmol/L

1.22 (0.91–1.63)

1.65 (1.04–2.38)

< 0.001

1.46 (1.00-2.15)

0.611 (0.455–0.820)

0.001

0.551 (0.318–0.955)

0.034

ApoA, g/L

0.15 (0.05–0.27)

0.32 (0.18–0.67)

0.013

0.26 (0.13–0.53)

0.070 (0.022–0.226)

< 0.001

0.200 (0.040–0.991)

0.049

ApoB, g/L

0.66 (044-0.92)

0.91 (0.61–1.23)

0.005

0.80 (0.55–1.14)

0.339 (0.188–0.610)

< 0.001

0.958 (0.638–1.439)

0.837

HDL-C, mmol/L

0.18 (0.11–0.29)

0.20 (0.14–0.55)

0.013

0.19 (0.13–0.40)

0.282 (0.111–0.717)

0.008

0.557 (0.128–2.419)

0.435

LDL-C, mmol/L

0.41 (0.20–1.22)

0.91 (0.25–1.80)

0.005

0.78 (0.24–1.52)

0.699 (0.527–0.926)

0.013

0.714 (0.432–1.179)

0.188

  1. NOTE: Data are presented as the median (Q1-Q3), the mean ± SD or the number of patients (%). The categorical data between two groups were compared with chi-square test or Fisher’s exact test. The continuous data between two groups were compared by t test or Mann-Whitney test. Univariate and Multivariate Cox regression models were used to assess the associations between various risk factors and different disease outcomes, as indicated. Nonsurvivors were determined by liver transplantation-free 90-day death.
  2. Abbreviations: LT, liver transplantation; HEV, hepatitis E virus; ACLF, acute-on-chronic liver failure; HR, Hazard ratio; CLDs, chronic liver diseases; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; TBA, total bile acid; Tbil, total bilirubin; Dbil, direct bilirubin; PTA, prothrombin activity; INR, international normalized ratio; PT, prothrombin; WBC, white blood cell; ApoA, apolipoprotein A; ApoB, apolipoprotein B; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NA, not available.
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Lipids in Health and Disease

ISSN: 1476-511X