A new dyslipidemia-based scoring model to predict transplant-free survival in patients with hepatitis E-triggered acute-on-chronic liver failure

Table 3 AUROCs for predicting the 28-day and 90-day mortality of patients with HEV-triggered ACLF.

Models	For predicting the 28-day mortality			For predicting the 90-day mortality
Models	AUROC (95% CI)	Z value	P value	AUROC (95% CI)	Z value	P value
Training set (n = 254)
HEV-T-ACLFs	0.878 (0.833–0.922)			0.896 (0.853–0.939)
MELD score	0.758 (0.689–0.827)	3.349	0.0008	0.784 (0.721–0.848)	3.467	0.0005
CTP score	0.836 (0.787–0.885)	2.153	0.0313	0.840 (0.790–0.890)	3.192	0.0014
CLIF-C OFs	0.774 (0.705–0.842)	3.061	0.0022	0.776 (0.710–0.842)	3.699	0.0002
CLIF-C ACLFs	0.742 (0.673–0.810)	3.625	0.0003	0.745 (0.681–0.810)	4.339	< 0.0001
COSSH ACLF IIs	0.831 (0.776–0.886)	1.610	0.1075	0.845 (0.792–0.898)	1.923	0.0545
Test set (n = 117)
HEV-T-ACLFs	0.892 (0.833–0.952)			0.906 (0.840–0.973)
MELD score	0.771 (0669-0.873)	2.232	0.0256	0.791 (0.702–0.881)	2.256	0.0241
CTP score	0.787 (0.688–0.887)	2.650	0.0080	0.799 (0.709–0.889)	2.888	0.0039
CLIF-C OFs	0.768 (0.672–0.864)	2.437	0.0148	0.813 (0.729–0.896)	1.948	0.0514
CLIF-C ACLFs	0.704 (0.583–0.862)	2.683	0.0073	0.735 (0.627–0.842)	2.667	0.0077
COSSH ACLF IIs	0.770 (0.658–0.882)	1.941	0.0523	0.808 (0.710–0.906)	1.739	0.0821

NOTE: AUROCs for different models were calculated and compared using the Z test (Delong’s method). The optimal cut-of points were determined by maximizing Youden index.
Abbreviations: AUROC, area under the receiver operating characteristic curve; HEV, hepatitis E virus; ACLF, acute-on chronic liver failure; HEV-T-ACLFs, HEV triggered ACLF score; MELD score, model for end-stage liver disease score; CTP score, Child-Turcotte-Pugh score; CLIF-C OFs, Chronic Liver Failure-Consortium (CLIF) organ failure score; COSSH ACLF IIs, Chinese Group on the Study of Severe Hepatitis B acute-on chronic liver failure II score.

ISSN: 1476-511X