Fig. 3

The identified proteins of the S/M/L-HDL subclasses in human and rat samples. a Heatmap of the ratios of the sum of peptide count for each protein in the S/M/L-HDL subclasses from human and rat samples. A equal volume of HDL subclasses were applied to the CSH resin, trypsinized, and then identified via LC‒MS/MS. The ratios of the sum of peptide count for each protein in the three HDL subclasses were calculated according to the unique peptide count of MS data, and a value of 1.0 was assigned to the subclass containing the highest peptide count for that particular protein and the peptide count of the other subclasses were scaled accordingly. the highest ratio (1.0) are colored red and gradually changed to yellow for the lower values, the lowest ratio (0.0) are colored green. The distinct proteins in the HDL subclass are shown in red font. b The distribution and overlaps of the proteins with the peptide count ratio of 1.0 among the HDL subclasses. The venn diagrams of the proteins with the peptide count ratio of 1.0 in each S/M/L-HDL subclass were drawn