Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study

Table 2 Cox regression analysis for the association of increased hs-CRP with stroke, CHD, and CVD

Outcome	Exposure group	Incidence cases	Person-years	Incidence density (/10⁴ person-years)	HR (95% CI)	P
Stroke
	Overall
	hs-CRP < 1 mg/L	171	28400.96	60.21	Ref
	hs-CRP ≥ 1 mg/L	236	21631.78	109.10	1.25 (1.03–1.54)	0.030*
	Dyslipidemia
	Yes
	hs-CRP < 1 mg/L	63	8788.92	71.68	Ref
	hs-CRP ≥ 1 mg/L	101	9108.70	110.88	1.19 (0.86–1.66)	0.296
	No
	hs-CRP < 1 mg/L	108	19612.03	55.07	Ref
	hs-CRP ≥ 1 mg/L	135	12523.08	107.80	1.34 (1.03–1.74)	0.030*
	P for heterogeneity					0.583
CHD
	Overall
	hs-CRP < 1 mg/L	103	28574.96	36.05	Ref
	hs-CRP ≥ 1 mg/L	138	22005.62	67.71	1.25 (0.96–1.64)	0.098
	Dyslipidemia
	Yes	47	8772.85	53.57	Ref
	hs-CRP < 1 mg/L	63	9353.41	67.36	1.06 (0.72–1.58)	0.759
	hs-CRP ≥ 1 mg/L
	No
	hs-CRP < 1 mg/L	56	19802.11	28.28	Ref
	hs-CRP ≥ 1 mg/L	75	12652.21	59.28	1.41 (0.99–2.02)	0.058
	P for heterogeneity					0.307
CVD
	Overall
	hs-CRP < 1 mg/L	240	27732.35	86.54	Ref
	hs-CRP ≥ 1 mg/L	327	20607.06	158.68	1.30 (1.09–1.54)	0.004*
	Dyslipidemia
	Yes
	hs-CRP < 1 mg/L	98	8437.70	116.15	Ref
	hs-CRP ≥ 1 mg/L	147	8667.95	169.59	1.17 (0.89–1.53)	0.255
	No
	hs-CRP < 1 mg/L	142	19294.65	73.60	Ref
	hs-CRP ≥ 1 mg/L	180	11939.11	150.77	1.42 (1.14–1.79)	0.002*
	P for heterogeneity					0.283

Notes: *: Significance at 0.05. The model was adjusted for age, gender, smoking, drinking, hypertension, BMI, and diabetes. BMI: body mass index; CVD: cardiovascular disease, CHD: coronary heart disease, hs-CRP: high-sensitivity C-reactive protein. HR: hazard ratio, CI: confidence intervals

ISSN: 1476-511X