Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study

Table 3 The interaction analysis of abnormal lipid levels and hs-CRP ≥ 1 mg/L for stroke, CHD, and CVD

Interaction terms	Additive interaction			Multiplicative interaction
Interaction terms	RERI (95% CI)	AP (95% CI)	P	HR (95% CI)	P
Stroke
hs-CRP ≥ 1 mg/L×LDL-C ≥ 160 mg/dL	-1.397 (-2.690- -0.104)	-1.440 (-3.286-0.407)	0.034*	0.357 (0.154–0.826)	0.016*
CHD
hs-CRP ≥ 1 mg/L×HDL-C < 40 mg/dL	-0.984 (-2.105-0.138)	-0.712 (-1.663-0.237)	0.087	0.499 (0.259–0.963)	0.038*
hs-CRP ≥ 1 mg/L×ApoAI < 1.60 g/L	-0.813 (-1.766-1.140)	-0.454 (-1.007-0.099)	0.094	0.552 (0.325–0.935)	0.027*
hs-CRP ≥ 1 mg/L×ApoB < 0.70 g/L	-0.992 (-2.106-0.122)	-0.627 (-1.478-0.225)	0.081	0.509 (0.275–0.942)	0.031*
CVD
hs-CRP ≥ 1 mg/L×LDL-C ≥ 160 mg/dL	-1.721 (-2.916- -0.526)	-1.704 (-3.430-0.021)	0.005*	0.309 (0.153–0.621)	0.001*
hs-CRP ≥ 1 mg/L×Non-HDL-C ≥ 190 mg/dL	-0.991 (-1.955- -0.028)	-0.694 (-1.476-0.089)	0.044*	0.505 (0.295–0.866)	0.013*
hs-CRP ≥ 1 mg/L×ApoB < 0.70 g/L	-0.444 (-1.028-0.140)	-0.338 (-0.813-0.138)	0.136	0.691 (0.449–1.065)	0.094

Notes: The model was adjusted for age, gender, smoking, drinking, hypertension, BMI, and diabetes. Hs-CRP: high sensitivity C-reactive Protein, CHD: coronary heart disease, CVD: cardiovascular disease, HDL-C: high-density lipoprotein cholesterol, LDL-C: low-density lipoprotein cholesterol, BMI: body mass index, ApoAI: apolipoprotein AI, ApoB: apolipoprotein B HR: hazard ratio, CI: confidence intervals, RERI: relative excessive risk interaction, AP: attributable proportion

ISSN: 1476-511X