Table 1 The DLCN scores of participants in this family

First-degree relative with premature coronary and/or vascular disease (men ≤ 55 years, women ≤ 60 years), OR

1

2

2

2

2

2

2

First-degree relative with known LDL-cholesterol ≥ 95th percentile for age and sex

1

First-degree relative with tendon xanthomata and/or arcus cornelis, OR

2

Children aged ≤ 18 years with known LDL-cholesterol ≥ 95th percentile for age and sex

2

Clinical History

Patient with premature coronary artery disease (age as above)

2

1

0

0

2

0

0

Patient with premature cerebral or peripheral vascular disease (age as above)

1

Physical Examination

Tendon Xanthomas

6

4

0

0

4

0

0

Arcus Cornelis at age ≤ 45 years

4

LDL Cholesterol (mmol/L) (mg/dL)

LDL-C ≥ 8.5 (330)

8

LDL-C 6.5–8.4 (250–329)

5

5

0

0

5

0

5

LDL-C 5.0-6.4 (190–249)

3

LDL-C 4.0-4.9 (155–189)

1

DNA Analysis – functional mutation LDLR, APOB and PCSK9

8

/

/

/

8

0

8

Total Score

12

2

2

21

2

15