Table 4 Hazard ratios for the outcomes by cumulative CVAI indicators stratified by age, sex, and blood pressure target attainment

Index

Age < 60

Age ≥ 60

Male

Female

No

Yes

Quartile 1

Reference

Reference

Reference

Reference

Reference

Reference

Quartile 2

1.19(0.92–1.54)

1.17(0.90–1.52)

1.16(0.96–1.41)

1.78(0.96–3.31)

1.16(0.95–1.41)

1.32(0.86–2.04)

Quartile 3

1.52(1.16–1.98)

1.16(0.90–1.50)

1.24(1.02–1.50)

1.40(0.74–2.66)

1.23(1.01–1.50)

1.36(0.87–2.12)

Quartile 4

1.54(1.20–1.98)

1.14(0.88–1.46)

1.37(1.14–1.65)

1.81(0.95–3.43)

1.30(1.07–1.58)

1.43(0.90–2.27)

P for interaction

0.10

0.19

0.50

TWA-CVAI

Quartile 1

Reference

Reference

Reference

Reference

Reference

Reference

Quartile 2

1.05(0.81–1.38)

1.06(0.83–1.36)

1.08(0.89–1.30)

1.30(0.71–2.38)

1.06(0.87–1.29)

1.07(0.68–1.67)

Quartile 3

1.59(1.22–2.07)

1.07(0.84–1.35)

1.25(1.04–1.51)

1.43(0.79–2.60)

1.23(1.01–1.49)

1.40(0.91–2.16)

Quartile 4

1.66(1.29–2.13)

1.10(0.86–1.40)

1.36(1.13–1.63)

1.60(0.87–2.95)

1.30(1.08–1.58)

1.41(0.90–2.23)

P for interaction

< 0.01

0.74

0.42

Cumulative burden

= 0

Reference

Reference

Reference

Reference

Reference

Reference

> 0

1.57(1.31–1.88)

1.05(0.90–1.23)

1.24(1.09–1.41)

1.35(0.92–1.97)

1.23(1.08–1.40)

1.31(0.96–1.79)

P for interaction

< 0.01

0.53

0.22

Time exposure duration

0 year

Reference

Reference

Reference

Reference

Reference

Reference

2 years

1.07(0.79–1.45)

1.29(0.97–1.71)

1.24(0.99–1.54)

1.06(0.58–1.94)

1.23(0.98–1.53)

1.26(0.76–2.09)

4 years

1.28(0.95–1.74)

1.05(0.78–1.41)

1.18(0.94–1.48)

1.29(0.68–2.41)

1.19(0.95–1.50)

1.27(0.75–2.15)

6 years

1.68(1.26–2.25)

1.17(0.88–1.55)

1.43(1.15–1.78)

1.09(0.60–1.98)

1.36(1.09–1.70)

1.66(1.00-2.76)

Index

age

sex

blood pressure target attainment

Age < 60

Age ≥ 60

Male

Female

No

Yes

8 years

1.65(1.17–2.31)

1.18(0.89–1.57)

1.46(1.17–1.82)

1.20(0.68–2.11)

1.37(1.10–1.71)

1.77(1.05–2.99)

10 years

1.79(1.33–2.42)

1.25(0.92–1.68)

1.46(1.14–1.86)

1.26(0.72–2.23)

1.39(1.09–1.76)

1.39(0.77–2.53)

P for interaction

0.02

0.95

0.59

Combination of CumCVAI and CVAI slope

CumCVAI < median Slope < 0

Reference

Reference

Reference

Reference

Reference

Reference

CumCVAI < median Slope ≥ 0

0.97(0.81–1.17)

0.92(0.71–1.18)

1.04(0.86–1.26)

0.70(0.39–1.26)

0.95(0.78–1.16)

1.28(0.81–2.02)

CumCVAI ≥ median, Slope < 0

1.17(0.96–1.42)

0.97(0.76–1.25)

1.16(0.94–1.42)

0.73(0.38–1.41)

1.07(0.87–1.32)

1.44(0.85–2.44)

CumCVAI ≥ median, Slope ≥ 0

1.23(1.04–1.47)

1.00(0.80–1.26)

1.27(1.05–1.52)

0.84(0.48–1.48)

1.19(1.00-1.44)

1.35(0.85–2.15)

P for interaction

0.06

0.63

0.51