Table 5 Sensitivity analyses for the association between cumulative CVAI indicators and CVD.

CumCVAI

Quartile 1

Reference

Reference

Reference

Reference

Quartile 2

1.21(1.01–1.45)

1.16(0.96–1.41)

1.31(1.06–1.62)

1.19(0.99–1.44)

Quartile 3

1.29(1.07–1.54)

1.25(1.03–1.52)

1.41(1.14–1.74)

1.30(1.08–1.57)

Quartile 4

1.35(1.13–1.61)

1.33(1.10–1.61)

1.42(1.15–1.74)

1.36(1.14–1.63)

TWA-CVAI

Quartile 1

Reference

Reference

Reference

Reference

Quartile 2

1.08(0.90–1.30)

1.07(0.88–1.31)

1.09(0.88–1.35)

1.06(0.88–1.28)

Quartile 3

1.26(1.06–1.51)

1.27(1.05–1.54)

1.34(1.09–1.65)

1.27(1.06–1.52)

Quartile 4

1.35(1.13–1.61)

1.35(1.12–1.62)

1.49(1.22–1.82)

1.35(1.14–1.61)

Cumulative burden of CVAI

= 0

Reference

Reference

Reference

Reference

> 0

1.24(1.10–1.40)

1.27(1.11–1.44)

1.32(1.15–1.52)

1.26(1.12–1.43)

Time exposure duration

0 year

Reference

Reference

Reference

Reference

2 years

1.21(0.98–1.48)

1.30(1.04–1.62)

1.28(1.00-1.63)

1.23(1.00-1.52)

4 years

1.17(0.95–1.44)

1.13(0.89–1.42)

1.19(0.92–1.53)

1.19(0.96–1.47)

6 years

1.38(1.13–1.70)

1.39(1.12–1.73)

1.40(1.10–1.79)

1.39(1.13–1.71)

8 years

1.41(1.14–1.73)

1.42(1.14–1.78)

1.46(1.14–1.87)

1.43(1.14–1.79)

10 years

1.42(1.14–1.78)

1.45(1.14–1.84)

1.47(1.15–1.87)

1.45(1.18–1.79)

Index

Sensitivity analysis ^a

Sensitivity analysis ^b

Sensitivity analysis ^c

Sensitivity analysis ^d

Combination of CumCVAI and CVAI slope

CumCVAI < median, Slope < 0

Reference

Reference

Reference

Reference

CumCVAI < median, Slope ≥ 0

1.01(0.84–1.22)

1.07(0.87–1.30)

1.07(0.87–1.30)

1.02(0.84–1.23)

CumCVAI ≥ median, Slope < 0

1.11(0.91–1.35)

1.15(0.93–1.42)

1.15(0.93–1.42)

1.13(0.93–1.38)

CumCVAI ≥ median, Slope ≥ 0

1.22(1.03–1.46)

1.28(1.06–1.55)

1.28(1.06–1.55)

1.26(1.06–1.51)