Table 2 Blood coagulation markers (median; IQR) according to Fatty Liver Index (FLI) categories in all participantsa and stratified by glucose tolerance status
From: Association between fatty liver index and blood coagulation markers: a population-based study
Total sample (n = 776) | FLIb | |||
|---|---|---|---|---|
no hepatic steatosis [FLI < 30] | intermediate status [FLI 30–59] | hepatic steatosis [FLI ≥ 60] | P valuee | |
n = 287 | n = 163 | n = 326 |  | |
Antithrombin III [mg/dL] | 105.5 (99.0;112.5) | 102.1 (96.0;107.9) | 98.9 (92.5;106.0) | < 0.001 |
D-dimers[μg[l/ | 367.0 (276.0;506.0) | 408.0 (330.0;557.0) | 438.5 (334.0;624.0) | < 0.001 |
Faktor VIII [%] | 116.8 (93.8;139.3) | 117.3 (94.1;137.9) | 125.8 (103.4;151.4) | < 0.001 |
Fibrinogen D [mg/dL] | 280.6 (249.1;316.0) | 298.4 (265.4;336.1) | 307.4 (268.5;345.4) | < 0.001 |
aPTT [s]c | 30.7 (28.6;33.1) | 30.8 (29.1;32.8) | 30.6 (28.6;32.8) | 0.671 |
Protein C [%] | 122.5 (111.7;136.8) | 124.9 (112.0;140.9) | 124.2 (111.8;140.3) | 0.207 |
Protein S [%] | 115.9 (98.8;132.9) | 131.3 (107.8;150.3) | 132.1 (112.9;153.0) | < 0.001 |
Quick value [%] | 107.3 (100.2;112.6) | 109.2 (103.1;115.5) | 109.4 (103.7;115.7) | 0.001 |
INRd | 1.0 (0.9;1.0) | 1.0 (0.9;1.0) | 1.0 (0.9;1.0) | 0.001 |
Normal glucose tolerance (n = 377) | n = 194 | n = 78 | n = 105 |  |
Antithrombin III [mg/dL] | 105.5 (99.1;112.5) | 102.4 (96.2;108.7) | 100.7 (95.2;107.5) | < 0.001 |
D-dimers[μg[l/ | 348.0 (270.0;470.0) | 379.0 (296.0;607.0) | 429.0 (332.0;602.0) | < 0.001 |
Faktor VIII [%] | 116.1 (91.7;139.0) | 113.0 (95.6;134.8) | 123.5 (100.3;143.5) | 0.134 |
Fibrinogen D [mg/dL] | 277.3 (248.8;305.6) | 297.5 (260.2;334.6) | 302.3 (262.3;342.8) | < 0.001 |
aPTT [s]c | 30.7 (28.7;33.1) | 30.08 (29.1;33.3) | 31.3 (29.0;33.3) | 0.644 |
Protein C [%] | 122.4 (109.6;136.5) | 127.8 (114.8;140.9) | 127.5 (113.7;139.2) | 0.055 |
Protein S [%] | 111.5 (96.7;129.6) | 132.2 (106.6;152.5) | 132.1 (110.1;162.3) | < 0.001 |
Quick value [%] | 106.4 (99.7;111.6) | 109.5 (103.2;115.8) | 108.9 (103.0;117.7) | 0.006 |
INRd | 1.0 (0.9;1.0) | 1.0 (0.9;1.0) | 1.0 (0.9;1.0) | 0.005 |
Prediabetes (n = 303) | n = 84 | n = 72 | n = 147 |  |
Antithrombin III [mg/dL] | 105.6 (97.0;110.4) | 100.9 (95.4;106.2) | 98.5 (91.2;105.3) | < 0.001 |
D-dimers[μg[l/ | 414.5 (333.0;562.0) | 415.5 (349.0;516.0) | 430.0 (326.0;606.0) | 0.871 |
Faktor VIII [%] | 116.8 (95.9;139.4) | 119.0 (93.4;142.1) | 125.5 (101.7;150.9) | 0.056 |
Fibrinogen D [mg/dL] | 296.3 (250.3;347.5) | 296.8 (269.7;340.0) | 310.3 (271.0;341.6) | 0.468 |
aPTT [s]c | 31.1 (28.6;33.6) | 30.8 (28.8;32.8) | 30.1 (28.2;32.6) | 0.201 |
Protein C [%] | 123.5 (112.4;137.5) | 122.3 (111.4;133.4) | 123.5 (111.6;140.1) | 0.959 |
Protein S [%] | 123.8 (105.1;140.7) | 130.2 (109.5;148.9) | 134.2 (113.9;150.2) | 0.050 |
Quick value [%] | 108.8 (102.8;115.0) | 108.8 (101.9;114.8) | 110.5 (104.6;115.5) | 0.381 |
INRd | 1.0 (0.9;1.0) | 1.0 (0.9;1.0) | 0.9 (0.9;1.0) | 0.396 |
Diabetes newly diagnosed and known (n = 84) | n = 6 | n = 10 | n = 68 |  |
Antithrombin III [mg/dL] | 109.8 (98.3;121.0) | 104.4 (97.8;109.7) | 96.3 (91.4;104.0) | 0.038 |
D-dimers[μg[l/ | 419.0 (289.0;552.0) | 511.5 (429.0;874.0) | 499.5 (374.5;716.0) | 0.486 |
Faktor VIII [%] | 137.1 (97.4;177.7) | 122.3 (115.8;139.8) | 136.6 (114.1;162.5) | 0.355 |
Fibrinogen D [mg/dL] | 299.9 (274.8;356.5) | 304.0 (284.0;318.3) | 313.2 (277.1;349.9) | 0.786 |
aPTT [s]c | 28.4 (25.5;30.4) | 31.1 (29.6;32.9) | 30.6 (28.8;32.7) | 0.108 |
Protein C [%] | 124.3 (119.7;133.1) | 124.6 (114.3;141.1) | 120.9 (110.6;142.0) | 0.919 |
Protein S [%] | 104.9 (94.4;137.3) | 134.5 (122.3;156.7) | 130.9 (112.8;146.4) | 0.242 |
Quick value [%] | 113.4 (108.4;121.0) | 111.1 (103.6;116.1) | 108.7 (101.6;115.7) | 0.297 |
INRd | 0.9 (0.9;1.0) | 0.9 (0.9;1.0) | 1.0 (0.9;1.0) | 0.286 |