Fig. 2
From: Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis
Deficiency of HO-1 exacerbates HFD-fed mice in terms of biochemical parameters and liver injury. (A) Body weight gain, (B) liver weight/body weight, and (C) fat mass in WT and HO-1HEPKO mice fed normal chow and HFD. Serum (D) ALT, (E) AST, (F) TC, (G) TG, and (H) fasting blood glucose in each group. (I) Western blot analysis of IL-6, IL-1β, and TNFα in liver tissue. (J) Western blot analysis of LOXL2, α-SMA, and TGFβ in liver tissue. Values are the mean ± SD (n = 6 per group). *P < 0.05, **P < 0.01 compared to the WT ND group; #P < 0.05, ##P < 0.01 compared to the WT HFD group