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Table 3 Univariate and multivariate analyses of factors associated with CKD (n = 1022)

From: Metabolic disorders induced by PNPLA3 and TM6SF2 gene variants affect chronic kidney disease in patients infected with non-genotype 3 hepatitis C virus

Variable

Univariate analysis

Multivariate analysis

OR (95%CI)

P

OR (95%CI)

P value

BMI > 23 kg/m2

2.23(1.61,3.09)

< 0.001

1.62(1.13,2.32)

0.009

HOMA-IR ≥ 2.5

2.25 (1.66,3.05)

< 0.001

1.71 (1.22,2.40)

0.002

Hypertension

4.29 (2.87,6.42)

< 0.001

4.06 (2.62,6.30)

< 0.001

TC

1.26 (1.07,1.48)

0.006

1.16 (0.97,1.39)

0.113

TG ≥ 1.7 mmol/L

2.66 (1.73,4.09)

< 0.001

2.30 (1.46,3.62)

< 0.001

CRP > 2 mg/L

1.42 (1.05,1.91)

0.023

1.34 (0.97,1.86)

0.078

LDL-C

1.41 (1.09,1.82)

0.010

1.26 (0.95,1.67)

0.116

HDL-C

0.78 (0.48,1.29)

0.341

0.68 (0.39,1.18)

0.170

CAP

1.01 (1.00,1.01)

0.002

1.00 (0.99,1.00)

0.224

Liver steatosis

1.91 (1.41,2.57)

< 0.001

2.11 (1.24,3.60)

0.006

PNPLA3 C > G

1.78 (1.31,2.42)

< 0.001

1.65 (1.18,2.31)

0.003

TM6SF2 C > T

0.39 (0.23,0.66)

< 0.001

0.40 (0.22,0.70)

0.001

  1. Abbreviations: See Table 1
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Lipids in Health and Disease

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