Table 1 Baseline characteristics of included studies assessing composite lipid indices in OSA
Author | Year | Design | Lipid index | Populations | Sample Size | Age | BMI Total | % Male total | Findings | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Main population | Control population | N Total | N Control | Age Total | Age control | |||||||
Bianchi et al | 2014 | Cross-sectional | LAP | Elderly patients with aortic aneurysms and high risk for OSA | Elderly patients with aortic aneurysms and low risk for OSA | 302 | 119 | 73.4 (8.6) | 74.7 (8.8) | 29.6 (6.2) | 86.5 | LAP was significantly higher in patients with higher risk of OSA (50.5 (35.5) vs. 36.7 (28.3), P < 0.001) |
Bikov et al | 2021 | Cross-sectional | AIP | Patients with a diagnosis of OSA (AHI ≥ 5) | Non-OSA individuals | 560 | 99 | 52.7 (13.4) | 46.7 (18.8) | 30.7 (5.5) | 58.9 | AIP was significantly higher in patients with OSA compared to controls (0.18 [0.03 to 0.31] vs. -0.15 [-0.34 to 0.06], P < 0.001) |
Bikov et al | 2022 | Cross-sectional | AIP, LAP, VAI | OSA patients with mild (AHI: 5–14.9), moderate (AHI 15–29.9), and severe (AHI ≥ 30) | Non-OSA control volunteers | 806 | 139 | 53.6 (13.0) | 45.2 (14.6) | 32.8 (6.0) | 66.4 | AIP, LAP, and VAI were all significantly different between the OSA group and healthy controls (P < 0.01) |
Cai et al | 2022 | Cross-sectional | AIP | Hypertensive patients with OSA | NA | 2281 | NA | 49.5 (10.4) | NA | 28.4 (3.8) | 68.5 | There was a J-shaped relationship between AIP and new-onset MI |
Cao et al | 2020 | Retrospective cohort | AIP | OSA patients with mild (AHI: 5–14.9), moderate (AHI 15–29.9), and severe (AHI ≥ 30) | Non-OSA controls | 284 | 28 | 45.3 (11.1) | 48.1 (12.6) | 27.2 (3.1) | 89.8 | AIP was significantly different between all groups (P < 0.001) |
Chen et al | 2016 | Cross-sectional | VAI | Patients with diagnosis of OSA based on AHI (mild, moderate, and severe) | Non-OSA patients (AHI 0–5) | 411 | 50 | 48.8 (13.6) | 44.4 (16.2) | 26.5 (3.0) | 75.9 | There was a significant difference in terms of VAI between controls and severe OSA, mild OSA and severe OSA, and also moderate OSA and severe OSA (P < 0.05) |
Dong et al | 2020 | Cross-sectional | LAP | Type 2 diabetic patients with OSA | Type 2 diabetic patients without OSA | 317 | 112 | 52.4 (14.1) | 47.1 (14.8) | 27.9 (4.1) | 69.1 | With a P of < 0.01, a significant difference was observed between OSA and non-OSA individuals |
Kim et al | 2020 | Retrospective cohort | AIP | Patients with a diagnosis of OSA based on AHI (mild, moderate, and severe) | Non-OSA individuals | 180 | NR | 48.6 (13.8) | NR | 26.4 (4.1) | 73.9 | AIP was significantly associated with OSA (P = 0.022); however, it was not an independent risk factor for OSA |
Mazzuca et al | 2014 | Retrospective cohort | VAI | Patients with diagnosis of OSA | Non-OSA controls | 528 | 55 | 51.3 (12.8) | 45.9 (15.4) | 31.0 (6.2) | 80.1 | VAI was not different between severities of OSA (P = 0.154) |
Meszaros et al | 2021 | Cross-sectional | AIP | Patients with diagnosis of OSA | Non-OSA controls | 76 | 30 | 48.9 (14.0) | 41.2 (16.3) | 28.2 (8.0) | 50.0 | Patients with OSA had significantly higher AIP compared to non-OSA ones |
Otelea et al | 2021 | Cross-sectional | AIP | Patients with asthma and OSA | Patients with asthma without OSA | 97 | 26 | 53.4 (6.8) | 51.0 (4.9) | 34.3 (7.1) | 69.1 | AIP values were significantly higher in OSA patients compared to patients with asthma (P = 0.04) |
Wei et al | 2021 | Cross-sectional | LAP, VAI | Patients with diagnosis of OSA | Non-OSA controls | 4747 | 909 | NR | NR | NR | NR | LAP and VAI were higher in OSA patients compared to non-OSA individuals |
Wysocki et al | 2016 | Prospective cohort | AIP | OSA patients (mild, moderate, and severe) without previous treatment | NA | 211 | NA | 50.4 (12.7) | NA | 30.4 (5.4) | 83.4 | AIP values were significantly higher in higher severities of OSA (P = 0.0121) |
Zou et al | 2020 | Cross-sectional | LAP, VAI | Patients with diagnosis of OSA | Non-OSA controls | 4703 | 890 | 42.3 (13.1) | NR | 26.4 (3.5) | 80.0 | LAP showed moderate efficiency as a screening tool for OSA |