Fig. 1

Biological mechanisms and signaling pathways between lipid metabolism and EC

Yellow boxes indicate factors that are closely associated with the development of EC. Light blue boxes indicate signaling pathways. The green color indicates inflammatory factors. The yellow arrow indicates an increase. The green downward arrow indicates a decrease. IR: Insulin resistance; IGF1: Insulin-like growth factor 1; EGRF: epidermal growth factor receptor; ECS: endometrial cells; VEGFR: vascular endothelial growth factor receptor; E: estrogen; E1: estrone; E2: estradiol; P: progesterone. IRAK1: interleukin-1 receptor-associated kinase 1. HIF-1α: hypoxia-inducible factor-1α; Ang: angiopoietin; GPER: G protein-coupled estrogen receptor. The dotted box indicates the pathways through which each inflammatory factor acts