Table 2 Biological mechanisms between lipid metabolism and EC

HDL-C

HDL→ApoA I→T-cell→MNC→TNF-α, IL-1β↓→Inflammatory factors

HDL→ApoA I→M2→M1↑→Antitumor

LDL-C

LDL→LDLR→ROS→PI3K/MAP↑→Carcinogenic effect

LDL→LDLR→ROS→NF-κB→HER2 PGF RAS EGFR↑→Genetic mutations

ROS→LDL-C→OX-LDL→CD36 LOX-1↑→Growth and metastasis

TC

TC→27HC→IL-6 TNF↑→Inflammatory factors

TC→27HC→ER↑→Uterine epithelial cell proliferation

TC→27HC→LXR↑→Growth and metastasis

TG

TG→SHBG + E→E↑→Angiogenesis and proliferation

TG→PPARα↑→Carcinogenic effect

TG→IHF→IR-A IGF-1R→PI3K/AKT ERK MAPK↑→Malignant phenotype