Table 2 Summarizing the important proteins involved in lipid metabolism in TMZ-resistant GBM

Fatty acid synthase

Enzyme involved in de novo fatty acid synthesis

Upregulation promotes TMZ resistance; inhibition sensitizes GBM cells to chemotherapy [36]

Sterol regulatory element-binding protein

Transcription factor that regulates expression of genes involved in cholesterol and fatty acid metabolism

Activation promotes TMZ resistance by upregulating fatty acid synthesis [42]

Acetyl-CoA carboxylase

Enzyme that converts acetyl-CoA to malonyl-CoA, precursor for fatty acid synthesis

Inhibition suppresses proliferation and migration in GBM cells [43]

Carnitine palmitoyltransferase 1 A

Enzyme involved in fatty acid oxidation

Inhibition sensitizes GBM cells to chemotherapy [44, 45]

Peroxisome proliferator-activated receptor gamma

Transcription factor that regulates expression of genes involved in lipid metabolism

Activation sensitizes TMZ-resistant GBM cells to chemotherapy by promoting lipid accumulation and inducing cell death [46, 47]